Kiran Soni
University of Delhi, India
Title: L-alanyl-4,6-O-ethylidene-β-D-glucopyranosylamine derived glycoconjugates and its application in metal interactions and amino acid interaction
Biography
Biography: Kiran Soni
Abstract
Glycoconjugates are the molecules in which sugar is connected to other organic species such as protein, peptide, amino acids etc via covalent interaction. They are divided in three classes O type, N type and C type. It is of general concern to produce the molecules that can imitate like biological system. Several reports have appeared on structural and function mimicking of biological activities. Protein and Carbohydrate are linked by an amido linkage between the carboxyl group of L-aspartic acid and the amino group of 2-acetamido-2-deoxy-β-D-glucopyranosylamine which is extracted either from hen egg albumin or from other source. N-(2-Hydroxybenzoyl)-L-alanyl-4,6-O-ethylidene-β-D-glucopyranosylamine was interacted with transition metal ions but solid product was not isolated, even though the solution phase study supported the interactions between them. A series of alanyl-(4,6-O-ethylidene-b-D-glucopyranosylamine) derived new chiral receptors have been synthesized. Metallochemistry of the ligands has been explored. N-(2-Hydroxybenzylidene)-L-alanyl-4,6-O-ethylidene-β-D-glucopyranosylamine (K1) interacts with the acetates of Zn(II), Cu(II), Ni(II), Mn(II) and Co(II) ions in ground state but the interaction remains conserved in excited state for Zn2+ ion only. K1 has been also used for the molecular recognition of naturally occurring amino acids. All the interactions studies were explored using UV-visible, fluorescence and mass spectroscopy.